Congratulations to Professor Sir Greg Winter who has been jointly awarded the 2018 Nobel Prize in Chemistry along with Frances Arnold and George Smith. Professor Winter has been awarded the prize for his pioneering work using phage display for the directed evolution of antibodies, with the aim of producing new pharmaceuticals.
The ground-breaking technology was developed by Professor Winter and the UK’s Medical Research Council in the 1990s via the company Cambridge Antibody Technology, which later became part of AstraZeneca.
The first clinically approved antibody based on this method, adalimumab, was approved in 2002 and is used to treat rheumatoid arthritis, psoriasis and inflammatory bowel diseases. Phage display has also been used to produce antibodies that can neutralise toxins, counteract autoimmune diseases and treat metastatic cancer.
Find out more about Professor Winter and his work.
We are proud to have been involved in protecting this Nobel Prize winning technology. Seán Walton, partner in our life sciences team, worked with Professor Winter on patents for phage display.